Individual Differences in the Response to Drugs

Completed 28 enrolled University of Chicago

RandomizedCrossoverTriple-blindBasic science

Summary

The purpose of this study is to examine whether individual differences in acute responses to drugs co-vary across three drugs from different drug classes: alcohol, amphetamine and delta-9-tetrahydrocannabinol (THC). The investigators hypothesize that individuals who experience greater rewarding effects from one drug will also experience more rewarding effects from the other drugs.

Timeline

Start: 2013-07
Primary completion: 2013-12
Completion: 2013-12

Publications

Wardle MC, Marcus BA, de Wit H. A Preliminary Investigation of Individual Differences in Subjective Responses to D-Amphetamine, Alcohol, and Delta-9-Tetrahydrocannabinol Using a Within-Subjects Randomized Trial. PLoS One. 2015 Oct 29;10(10):e0140501. doi: 10.1371/journal.pone.0140501. eCollection 2015.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	ALC	Unknown	0.8 g/kg	Oral
Subject	AMP	Unknown	20 mg	Oral
Subject	THC	Unknown	7.5 mg	Oral

Indications

No indication recorded.