The Effect of Sumatriptan and Placebo on Cilostazol Induced Headache

Summary

To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with a phosphodiesterase inhibitor (cilostazol). If the headache responds to sumatriptan, the model can be used to test new drug candidates.

Timeline

Start

2015-06

Primary completion

2016-06

Completion

2016-06

Publications

• Falkenberg K, Dunga BOA, Guo S, Ashina M, Olesen J. Cilostazol induced migraine does not respond to sumatriptan in a double blind trial. J Headache Pain. 2018 Feb 2;19(1):11. doi: 10.1186/s10194-018-0841-7.

Drugs

Indications