Bio-availability of Rectal Artesunate in Children With Severe Falciparum Malaria

Phase 2 Completed 82 enrolled University of Oxford Kinshasa School of Public Health · collab

RandomizedCrossoverOpen-labelBasic science

Summary

The study aims at describing the pharmacokinetic properties of rectal artesunate in well characterized severely ill patients using intravenous artesunate as a comparator.

Timeline

Start: 2015-07
Primary completion: 2015-10
Completion: 2015-10

Publications

Fanello C, Hoglund RM, Lee SJ, Kayembe D, Ndjowo P, Kabedi C, Badjanga BB, Niamyim P, Tarning J, Woodrow C, Gomes M, Day NP, White NJ, Onyamboko MA. Pharmacokinetic Study of Rectal Artesunate in Children with Severe Malaria in Africa. Antimicrob Agents Chemother. 2021 Mar 18;65(4):e02223-20. doi: 10.1128/AAC.02223-20. Print 2021 Mar 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Artesunate	Small molecule	2.4 mg/kg	Rectal
Subject	Artesunate	Small molecule	10 mg/kg	Rectal
Background	Quinine	Small molecule	10 mg/kg	Intravenous

Bio-availability of Rectal Artesunate in Children With Severe Falciparum Malaria

Summary

Timeline

Publications

Drugs

Indications