drugset / Trial / NCT02492217

Biomarkers Identification of Anti-tumor Necrosis Factor (TNF) α Agent's Efficacy in Ankylosing Spondylitis Patients

NCT02492217

Phase 4 Completed 69 enrolled NOVA University Lisbon
NaSingle-groupOpen-labelTreatment

Summary

To identify new candidate genes and proteins that are differentially expressed in responders' vs non-responders to anti-TNF alpha therapy at the several time points the investigators will use the transcriptomic and proteomic analyses. Demonstrate a link between gene expression and protein markers regarding prediction to anti-TNF alpha therapy efficacy.

Timeline

Start
2015-05
Primary completion
2018-05
Completion
2018-05-28

Drugs

EvaluationDrugModalityDoseRoute
Subject Adalimumab Monoclonal antibody 40 mg