Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults With ADPKD

Summary

The proposed research will determine the effectiveness of curcumin for improving the health and function of arteries in children and young adults with autosomal dominant polycystic kidney disease (ADPKD). The study also will provide insight into how curcumin improves artery health by determining the physiological mechanisms (biological reasons) involved and offer exploratory evidence if curcumin can slow kidney growth. This will be done by comparing these measurements in children and young adults who are randomized to receive either curcumin or placebo for 1 year.

Timeline

Start

2015-11-12

Primary completion

2021-02-01

Completion

2021-02-01

Outcome

Missed primary endpoint

paper Neither coprimary end point changed with curcumin PMID 34907021 ↗

paper Curcumin supplementation does not improve vascular function or slow kidney growth in children/young adults with ADPKD. PMID 34907021 ↗

Publications

• Nowak KL, Farmer-Bailey H, Wang W, You Z, Steele C, Cadnapaphornchai MA, Klawitter J, Patel N, George D, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD: A Randomized Controlled Trial. Clin J Am Soc Nephrol. 2022 Feb;17(2):240-250. doi: 10.2215/CJN.08950621. Epub 2021 Dec 14.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Curcumin	Small molecule	25 mg/kg	Oral

Indications