drugset / Trial / NCT02502006
Variability in Response to Non-steroidal Anti-inflammatory Drugs
Phase 1
Terminated
16 enrolled
University of Pennsylvania
National Heart, Lung, and Blood Institute (NHLBI) · collab
RandomizedCrossoverDouble-blindOther
Summary
This research study will evaluate inter-individual variability in the response to the non-steroidal anti-inflammatory drugs (NSAIDs), celecoxib and naproxen, among healthy adults. It will also investigate what factors, like age, sex, or genetic background, cause this variability.
Timeline
- Start
- 2015-11
- Primary completion
- 2022-09
- Completion
- 2022-09
Publications
- Theken KN, Ghosh S, Skarke C, Fries S, Lahens NF, Sarantopoulou D, Grant GR, FitzGerald GA, Grosser T. Degree of Cyclooxygenase-2 Inhibition Modulates Blood Pressure Response. Hypertension. 2026 Feb;83(2):e25516. doi: 10.1161/HYPERTENSIONAHA.124.25516. Epub 2025 Dec 29.
- Theken KN, Ghosh S, Skarke C, Fries S, Lahens NF, Sarantopoulou D, Grant GR, FitzGerald GA, Grosser T. Degree of Cyclooxygenase-2 Inhibition Modulates Blood Pressure Response to Celecoxib and Naproxen. medRxiv [Preprint]. 2024 May 31:2024.05.30.24308244. doi: 10.1101/2024.05.30.24308244.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Celecoxib | Other / unclassified | 100 mg | Oral |
| Subject | Celecoxib | Other / unclassified | 200 mg | Oral |
| Subject | Naproxen | Small molecule | 250 mg | Oral |
| Subject | Naproxen | Small molecule | 500 mg | Oral |
Indications
No indication recorded.