Subcutaneous Ketamine for Postoperative Pain Relief in Rwanda

Phase 2/3 Completed 61 enrolled University of Saskatchewan National University, Rwanda · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

A randomized double blind control trial to investigate the safety and efficacy of subcutaneous ketamine for control of post operative pain in low resource settings.

Timeline

Start: 2015-06
Primary completion: 2015-07
Completion: 2015-07

Outcome

Met primary endpoint

registry MEAN Ketamine: 3.5 (Standard Deviation 1.4) units on a scale MEAN Saline: 4.9 (Standard Deviation 1.6) units on a scale NCT02514122 ↗

registry analysis (superiority test); Ketamine vs Saline; p = 0.009; Mean Difference (Final Values) 0.83 (95% CI 0.29 to 1.9); NCT02514122 ↗

Publications

Sacevich C, Semakuba B, McKay WP, Thakore S, Twagirumugabe T, Nyiligira J. Subcutaneous ketamine for postoperative pain relief in Rwanda: a randomized clinical trial. Can J Anaesth. 2018 Feb;65(2):170-177. doi: 10.1007/s12630-017-1009-7. Epub 2017 Nov 13.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	1 mg/kg	Subcutaneous

Indications

No indication recorded.