Optimal Dosing of Ketamine for Procedural Sedation and Analgesia in Children

Summary

There is a wide variation of published IV ketamine dosing regimens used for procedural sedation in children in the Emergency Department (ED). The purpose of the study was to compare the efficacy, duration of sedation and adverse events between the three commonly administered doses of IV ketamine (1 mg/kg, 1.5 mg/kg and 2 mg/kg) using the traditional administration method of 30-60 second infusion for ED sedation in children.

Timeline

Start

2010-08

Primary completion

2012-08

Completion

2012-08

Outcome

Missed primary endpoint

registry Ketamine IV 1 mg/kg vs Ketamine IV 1.5 mg/kg vs Ketamine IV 2 mg/kg; p = 0.2; Kruskal-Wallis NCT02519595 ↗

registry Ketamine IV 1 mg/kg vs Ketamine IV 1.5 mg/kg vs Ketamine IV 2 mg/kg; p = 0.09; Kruskal-Wallis NCT02519595 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	1 mg/kg	Intravenous
Subject	Ketamine	Small molecule	1.5 mg/kg	Intravenous
Subject	Ketamine	Small molecule	2 mg/kg	Intravenous

Indications

No indication recorded.