Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression

Summary

In this proof of concept study, the investigators plan to administer iv ketamine interleaved with ECT days. Patients with treatment resistant depression who are deemed to be eligible for ECT treatment will randomly be assigned to either ketamine or active placebo.

Timeline

Start

2015-08

Primary completion

2018-03-01

Completion

2018-03-01

Outcome

Missed primary endpoint

registry analysis (superiority test); Ketamine Infusions vs Midazolam; p = 0.72; Mean Difference (Final Values) 1.22; Mixed Models Analysis NCT02522377 ↗

registry analysis (superiority test); Ketamine Infusions vs Midazolam; p = 0.77; Mean Difference (Final Values) 1.98; Mixed Models Analysis NCT02522377 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	—	Intravenous
Comparator	Midazolam	Small molecule	—	Intravenous

Indications