Effect of ACE-Inhibition on Microvascular Function in Women With Assessed Microvascular Dysfunction

Summary

The aim of this study is to explore effects of long term treatment with ACE-inhibitor on the small vessel function assessed by coronary flow reserve (CFR) by transthoracic echocardiography and flow mediated dilation in normotensive patients with small vessel disease (CFR\<2.2) and Angina Pectoris but no obstructive coronary artery disease.

Timeline

Start

2015-07

Primary completion

2016-07

Completion

2016-07

Outcome

Missed primary endpoint

paper In normotensive women with angina and CMD, treatment with ramipril had no significant effect on CFVR or symptoms compared with placebo. PMID 29883497 ↗

Publications

• Michelsen MM, Rask AB, Suhrs E, Raft KF, Host N, Prescott E. Effect of ACE-inhibition on coronary microvascular function and symptoms in normotensive women with microvascular angina: A randomized placebo-controlled trial. PLoS One. 2018 Jun 8;13(6):e0196962. doi: 10.1371/journal.pone.0196962. eCollection 2018.

Drugs

Indications