Magnetic Resonance-Guided High Intensity Focused Ultrasound for Recurrent Rectal Cancer

Summary

This pilot study hypothesizes that hyperthermia delivered via magnetic resonance-guided focused ultrasound (MRg-FU) is technically feasible and can be safely used in combination with concurrent reirradiation and chemotherapy for the treatment of recurrent rectal cancer. Twenty recurrent rectal cancer patients who are not candidates for surgery will be recruited for hyperthermia treatment delivered via MRg-FU concurrent with reirradiation and oral chemotherapy.

Timeline

Start

2015-04

Primary completion

2021-04

Completion

2022-04

Publications

• Peng J, Partanen A, Pichardo S, Staruch R, Perry K, McGuffin M, Huang Y, Chan KK, Wong S, Czarnota G, Hynynen K, Chu W. Mild hyperthermia with magnetic resonance- guided high intensity focused ultrasound combined with salvage chemoradiation for recurrent rectal cancer. Int J Hyperthermia. 2024;41(1):2365385. doi: 10.1080/02656736.2024.2365385. Epub 2024 Jun 19.

Drugs

Indications