Effectiveness of Second Generation Antipsychotics in First Episode Psychosis Patients: 1-year Follow-up

Summary

This study compares the efficacy and effectiveness of two of the second-generation antipsychotics (SGAs) most used in our society in the treatment of schizophrenia (Aripiprazole and Risperidone) and the investigators do within an assistance program of early-stage psychosis individuals of the Community of Cantabria, clinical reference for the treatment of this disease in the Spanish Autonomous Community. Patients are included in a prospective naturalistic study, open flexible-doses and randomized into one of two possible patterns of treatment that includes the protocol.

Timeline

Start

2014-05

Primary completion

2018-05

Completion

2020-12

Publications

• Garrido-Sanchez L, Gomez-Revuelta M, Ortiz-Garcia de la Foz V, Pelayo-Teran JM, Juncal-Ruiz M, Ruiz-Veguilla M, Mayoral-Van Son J, Ayesa-Arriola R, Vazquez-Bourgon J, Crespo-Facorro B. Aripiprazole vs Risperidone Head-to-Head Effectiveness in First-Episode Non-Affective-Psychosis: A 3-Month Randomized, Flexible-Dose, Open-Label Clinical Trial. Int J Neuropsychopharmacol. 2022 Nov 17;25(11):900-911. doi: 10.1093/ijnp/pyac047.
• Gomez-Revuelta M, Pelayo-Teran JM, Vazquez-Bourgon J, Ortiz-Garcia de la Foz V, Mayoral-van Son J, Ayesa-Arriola R, Crespo-Facorro B. Aripiprazole vs Risperidone for the acute-phase treatment of first-episode psychosis: A 6-week randomized, flexible-dose, open-label clinical trial. Eur Neuropsychopharmacol. 2021 Jun;47:74-85. doi: 10.1016/j.euroneuro.2021.02.009. Epub 2021 Mar 5.

Drugs

Indications