drugset / Trial / NCT02534207
Basmisanil Positron Emission Tomography Study in Japanese Volunteers
NaSingle-groupOpen-labelBasic science
Summary
This study will evaluate the relationship between basmisanil plasma concentrations and the occupancy of Gamma-Amino Butyric Acid A (GABAA) receptor subtypes containing an alpha5 (α5) subunit in healthy Japanese volunteers. Each participant will have two post-screening imaging sessions. In the first imaging session, participants will have a baseline Positron Emission Tomography (PET) scan. In the second imaging session, participants will receive a single oral dose of basmisanil, followed by two on-treatment PET scans at about 4 and 10 hours post-dose.
Timeline
- Start
- 2015-08
- Primary completion
- 2015-10
- Completion
- 2015-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Basmisanil | Small molecule | 160 mg | Oral |
| Subject | Basmisanil | Small molecule | 480 mg | Oral |
Indications
No indication recorded.