drugset / Trial / NCT02534558
Pathomechanism of MicroRNA-29 in Shoulder Stiffness
RandomizedParallel-groupTriple-blindDiagnostic
Summary
The team integrates experimental analyses of clinical and basic medicine and transgenic mice models. miR-29a acts a potent protective factor against excessive fibrosis in myofibroblasts of subacromial bursa tissue. Gain of miR-29a stabilizes tendon and synovial tissue homeostasis that alleviates tissue stiffness and maintains function.
Timeline
- Start
- 2014-08-01
- Primary completion
- 2019-07-31
- Completion
- 2019-07-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | miR-29a antisense oligonucleotide | Antisense oligonucleotide | — | — |
| Subject | miR-29a precursor oligonucleotide | Oligonucleotide (other) | — | — |