Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans

Phase 1 Completed 27 enrolled Vanderbilt University Medical Center National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab

RandomizedCrossoverSingle-blindBasic science

Summary

The overall hypothesis of this proposal is that nutrient sensing in the foregut regulates metabolic hormone secretion and nutrient metabolism via enteric neural signals, and these mechanisms might be defective in obesity.

Timeline

Start: 2015-09
Primary completion: 2022-12-08
Completion: 2022-12-08

Publications

Background Sundaresan S, Johnson C, Dixon KB, Dole M, Kilkelly D, Antoun J, Flynn CR, Abumrad NN, Tamboli R. Intraduodenal nutrient infusion differentially alters intestinal nutrient sensing, appetite, and satiety responses in lean and obese subjects. Am J Clin Nutr. 2023 Sep;118(3):646-656. doi: 10.1016/j.ajcnut.2023.06.011. Epub 2023 Aug 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Benzocaine	Small molecule	0.5 %	Other

Role of the Foregut in Nutrient Metabolism in Lean and Obese Humans

Summary

Timeline

Publications

Drugs

Indications