Tong-Xie-Yao-Fang Granules for Diarrhea-predominant Irritable Bowel Syndrome

Phase 2/3 Completed 160 enrolled Chengdu University of Traditional Chinese Medicine

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to test the efficacy and safety of a traditional Chinese medication Tong-Xie-Yao-Fang for patients with diarrhea-predominant irritable bowel Syndrome (IBS-D).

Timeline

Start: 2015-12
Primary completion: 2017-01
Completion: 2017-03

Outcome

Met primary endpoint

paper adequate relief of global symptoms in TXFY group during weeks 1 to 4 (57.5% vs 37.5%, χ2 = 5.6391, P = 0.017) PMID 29856472 ↗

Publications

Chen M, Tang TC, Wang Y, Shui J, Xiao XH, Lan X, Yu P, Zhang C, Wang SH, Yao J, Zheng H, Huang DQ. Randomised clinical trial: Tong-Xie-Yao-Fang granules versus placebo for patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2018 Jul;48(2):160-168. doi: 10.1111/apt.14817. Epub 2018 Jun 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tong-Xie-Yao-Fang	Traditional medicine (herbal / TCM)	15 g	—