Adductor Canal Block With Continuous Infusion Versus Intermittent Boluses and Morphine Consumption

Phase 4 Completed 110 enrolled Pia Jaeger Bispebjerg Hospital · collab Smiths Medical, ASD, Inc. · collab University of California, San Diego · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The investigators believe sufficient spread to all nerves within the adductor canal-and thereby sufficient analgesia-can only be obtained by bolus injections and not by continuous infusions via a catheter. The aim of the study is to investigate whether an adductor canal block performed as repeated intermittent boluses provides superior pain relief to continuous infusion. The investigators hypothesize that adductor canal block performed as intermittent boluses via a catheter will reduce morphine consumption and pain as well as enhance ambulation and muscle strength compared with continuous infusion.

Timeline

Start: 2015-03
Primary completion: 2016-09
Completion: 2016-09

Outcome

Missed primary endpoint

paper Changing the mode of administration for an ACB from continuous infusion to repeated intermittent boluses did not decrease opioid consumption, pain, nor mobility. PMID 29293181 ↗

Publications

Jaeger P, Baggesgaard J, Sorensen JK, Ilfeld BM, Gottschau B, Graungaard B, Dahl JB, Odgaard A, Grevstad U. Adductor Canal Block With Continuous Infusion Versus Intermittent Boluses and Morphine Consumption: A Randomized, Blinded, Controlled Clinical Trial. Anesth Analg. 2018 Jun;126(6):2069-2077. doi: 10.1213/ANE.0000000000002747.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ropivacaine	Other / unclassified	0.2 %	Other

Indications

No indication recorded.