The Anti-inflammatory Effect of Prophylactic Macrolides on Children With Chronic Lung Disease

Summary

The purpose of this study is to determine if the prophylactic use of azithromycin will reduce the total number of days when unscheduled treatment is given outside of the home in a clinic, urgent care, emergency room or hospital setting between the respiratory illness season months (October 1-March 31) and subsequent 2 month follow-up (April and May)

Timeline

Start

2015-10

Primary completion

2017-03-31

Completion

2017-03-31

Outcome

Missed primary endpoint

paper Macrolide prophylaxis did not lead to a significant reduction in the primary outcome of unscheduled healthcare encounter days PMID 41090256 ↗

Publications

• Mosquera RA, Yadav A, Romero-Lopez MDM, Magana-Ceballos IG, Hashmi SS, De Jesus Rojas W, Tellez ME, Riggs-Harpur K, Boricha FM, Reddy TS, John JL, Harris TS, Rodriguez-Martinez CE, Buendia J, McBeth KE, Jon CK, Stark JM, Colasurdo GN. The Effect of Chronic Azithromycin Use in Winter on Health Care Utilization for Children With Bronchopulmonary Dysplasia: A Double Blind Randomized Controlled Study (RCT). Pediatr Pulmonol. 2025 Oct;60(10):e71314. doi: 10.1002/ppul.71314.
• Mosquera RA, Gomez-Rubio AM, Harris T, Yadav A, McBeth K, Gonzales T, Jon C, Stark J, Avritscher E, Pedroza C, Smith K, Colasurdo G, Wootton S, Piedra P, Tyson JE, Samuels C. Anti-inflammatory effect of prophylactic macrolides on children with chronic lung disease: a protocol for a double-blinded randomised controlled trial. BMJ Open. 2016 Sep 16;6(9):e012060. doi: 10.1136/bmjopen-2016-012060.

Drugs

Indications