Effect of Vitamin D on Ventricular Remodeling in Patients With Acute Myocardial Infarction (VITDAMI)

Summary

To study the effect of calcifediol on left ventricular remodeling, mineral metabolism, plasma levels of several prognostic biomarkers and on endothelial function after an anterior myocardial infarction.

Timeline

Start

2015-10

Primary completion

2023-05

Completion

2023-05

Publications

• Tunon J, Rodriguez-Lopez C, Balaguer J, Gomez-Talavera S, Rojas A, Salamanca J, Garcia CL, Esteve-Pastor MA, Laffond A, Herrera C, Escudier-Villa JM, Orejas M, Tomas M, Alvarez ML, Tomeo MA, Llanos-Jimenez L, Gonzalez-Lorenzo O, Kallmeyer A, Ibanez B, Gonzalez-Casaus ML, Hernandez G, Espadas C, Lorenzo O, Mahillo-Fernandez I, Egido J, Sanchez PL, Marin F, Alfonso F. Vitamin D in the prevention of left ventricular remodelling after an acute myocardial infarction: a randomized clinical trial. Sci Rep. 2026 Apr 6;16(1):16486. doi: 10.1038/s41598-026-45330-6.
• Tunon J, Gonzalez-Hernandez I, Llanos-Jimenez L, Alonso-Martin J, Escudier-Villa JM, Tarin N, Cristobal C, Sanz P, Pello AM, Acena A, Carda R, Orejas M, Tomas M, Beltran P, Calero Rueda M, Marcos E, Serrano-Antolin JM, Gutierrez-Landaluce C, Jimenez R, Cabezudo J, Curcio A, Peces-Barba G, Gonzalez-Parra E, Munoz-Siscart R, Gonzalez-Casaus ML, Lorenzo A, Huelmos A, Goicolea J, Ibanez B, Hernandez G, Alonso-Pulpon LM, Farre J, Lorenzo O, Mahillo-Fernandez I, Egido J. Design and rationale of a multicentre, randomised, double-blind, placebo-controlled clinical trial to evaluate the effect of vitamin D on ventricular remodelling in patients with anterior myocardial infarction: the VITamin D in Acute Myocardial Infarction (VITDAMI) trial. BMJ Open. 2016 Aug 5;6(8):e011287. doi: 10.1136/bmjopen-2016-011287.

Drugs

Indications