Continued Versus Discontinued Oxytocin Stimulation of Labour

Summary

Background: The proposed study will investigate the effect of Syntocinon® (synthetic oxytocin) to induce labour. The hypothesis to be studied is that once the active phase of labour has commenced, Syntocinon® can be discontinued and the labour process will continue. Design: Double-blind randomised controlled multicentre trial Setting: Aarhus University Hospital, Denmark and Regional Hospital of Randers, Denmark Population: 1200 women (600 in each group) stimulated in the latent phase of labour with oxytocin for induction Methods: The Syntocinon® infusion will be replaced with either continuous isotonic saline (placebo) or Syntocinon® infusion (control group), when the active phase of labour is reached. Main outcome measures: Caesarean section (primary outcome), tachysystole, neonatal asphyxia, birth experience Perspective: Syntocinon® is on the list high-alert medications and associated with complications for mother and child during labour. Reducing the duration of stimulation during labour may lower the number of asphyxial sequelae and the number of caesarean sections.

Timeline

Start

2016-04

Primary completion

2020-07-01

Completion

2020-07-01

Publications

• Boie S, Glavind J, Uldbjerg N, Steer PJ, Bor P; CONDISOX trial group. Continued versus discontinued oxytocin stimulation in the active phase of labour (CONDISOX): double blind randomised controlled trial. BMJ. 2021 Apr 14;373:n716. doi: 10.1136/bmj.n716.
• Boie S, Glavind J, Uldbjerg N, Bakker JJH, van der Post JAM, Steer PJ, Bor P. CONDISOX- continued versus discontinued oxytocin stimulation of induced labour in a double-blind randomised controlled trial. BMC Pregnancy Childbirth. 2019 Sep 2;19(1):320. doi: 10.1186/s12884-019-2461-x.

Drugs

Indications

No indication recorded.