Prophylactic Topical Agents in Reducing Radiation-Induced Dermatitis in Patients With Non-inflammatory Breast Cancer
Summary
This randomized pilot phase II trial studies and compares prophylactic topical agents in reducing radiation-induced dermatitis in patients with non-inflammatory breast cancer or breast cancer in situ. The prophylactic topical agents, such as curcumin-based gel or HPR Plus, may reduce the severity of the radiation-induced dermatitis by minimizing water loss and inflammation during radiation therapy.
Timeline
- Start
- 2015-10-13
- Primary completion
- 2016-09-30
- Completion
- 2016-09-30
Outcome
Missed primary endpoint
registry analysis (other test); Arm I (Curcumin-based Gel) vs Arm II (HPR Plus) vs Arm III (Placebo Gel); p = 0.9306; ANOVA NCT02556632 ↗
registry analysis (other test); Arm I (Curcumin-based Gel) vs Arm II (HPR Plus) vs Arm III (Placebo Gel); p = 0.8048; Fisher Exact NCT02556632 ↗
registry analysis (other test); Arm I (Curcumin-based Gel) vs Arm II (HPR Plus) vs Arm III (Placebo Gel); p = 0.8591; ANOVA NCT02556632 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Curcumin | Small molecule | — | Topical |