Evaluation of the Discontinuation of Maintenance Corticosteroid Treatment in Quiescent Systemic Lupus

Summary

Systemic Lupus (SLE) is a chronic disease for which long term treatments are warranted. The aim of this study was to study the possibility of corticosteroids interruption in patients with quiescent SLE treated since at least one year with 5 milligrams of predonisone per day.

Timeline

Start

2014-01

Primary completion

2017-01

Completion

2018-01

Outcome

Met primary endpoint

paper Proportion of patients experiencing a flare was significantly lower in the maintenance group as compared with the withdrawal group PMID 31852672 ↗

paper (4 patients vs 17; RR 0.2 (95% CI 0.1 to 0.7), p=0.003) PMID 31852672 ↗

Publications

• Mathian A, Pha M, Haroche J, Cohen-Aubart F, Hie M, Pineton de Chambrun M, Boutin THD, Miyara M, Gorochov G, Yssel H, Cherin P, Devilliers H, Amoura Z. Withdrawal of low-dose prednisone in SLE patients with a clinically quiescent disease for more than 1 year: a randomised clinical trial. Ann Rheum Dis. 2020 Mar;79(3):339-346. doi: 10.1136/annrheumdis-2019-216303. Epub 2019 Dec 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Prednisone	Other / unclassified	5 mg	—

Indications