Randomized Trial of Continuous Versus Intermittent Cefotaxime Infusion on ICU.

Phase 4 Completed 60 enrolled University Medical Center Groningen

RandomizedParallel-groupOpen-labelBasic science

Summary

This study evaluates target attainment after either intermittent intravenous bolus or intravenous continuous infusion of cefotaxime in critically ill patients. Critically ill patients will be randomized to intermittent infusion or continuous infusion of cefotaxime.

Timeline

Start: 2015-11
Primary completion: 2016-06
Completion: 2016-09

Publications

Aardema H, Bult W, van Hateren K, Dieperink W, Touw DJ, Alffenaar JC, Zijlstra JG. Continuous versus intermittent infusion of cefotaxime in critically ill patients: a randomized controlled trial comparing plasma concentrations. J Antimicrob Chemother. 2020 Feb 1;75(2):441-448. doi: 10.1093/jac/dkz463.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cefotaxime	Small molecule	1000 mg	Intravenous
Subject	Cefotaxime	Small molecule	4000 mg	Intravenous

Indications

No indication recorded.