Glucocorticoids With Antihistamines Versus Antihistamines in Acute Urticaria in Emergency

Summary

Acute urticaria is common and affected 12% of population. 400 patients come in department emergency of Toulouse each year and there aren't many studies in literature which evaluate the glucocorticoids treatment. The standard treatment of urticaria is antihistamines H1, but glucocorticoids treatment administered orally for short course would permit to increase quickly acute urticaria uncomplicated. Clinical trial, prospective randomized double blinded of adults with acute urticaria less 24 hours duration and no take treatment urticaria before.

Timeline

Start

2012-02

Primary completion

2014-02

Completion

2014-02

Outcome

Missed primary endpoint

paper Levocetirizine and Prednisone Are Not Superior to Levocetirizine Alone for the Treatment of Acute Urticaria PMID 28476259 ↗

paper The addition of a prednisone burst did not improve the symptomatic and clinical response of acute urticaria to levocetirizine. PMID 28476259 ↗

Publications

• Results Barniol C, Dehours E, Mallet J, Houze-Cerfon CH, Lauque D, Charpentier S. Levocetirizine and Prednisone Are Not Superior to Levocetirizine Alone for the Treatment of Acute Urticaria: A Randomized Double-Blind Clinical Trial. Ann Emerg Med. 2018 Jan;71(1):125-131.e1. doi: 10.1016/j.annemergmed.2017.03.006. Epub 2017 May 3.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Prednisone	Other / unclassified	40 mg	Oral
Background	Levocetirizine	Unknown	5 mg	Oral

Indications