Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot Study

Summary

This is a pilot study. The objective is to further understand the mechanism by which amantadine improves function in patients with persistent vegetative state and minimally conscious state. Specifically, the investigators will measure the size of the nerve fibers that mediate arousal (reticular activating system, or RAS) pre and post treatment on MRI tractography. MRI findings will be correlated with the Disability Rating Scale (DRS) score. The information gathered from this study will be used to formulate a larger clinical trial.

Timeline

Start

2016-01

Primary completion

2016-12

Completion

2017-06

Drugs

Indications