The Effect of Oxycodone to the Placental Circulation at Early Labour

Phase 4 Unknown 22 enrolled Kuopio University Hospital Admescope Ltd · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

Oxycodone is used to treat pain in early labor, however the effect of oxycodone to placental or fetal circulation has not been evaluated. Oxycodone is increasingly used to treat labor pain in the early phase. The aim of the randomised, double blinded, placebo controlled study was to evaluate the effects of oxycodone in placental circulation, efficacy and safety of oxycodone and the effects to the newborn.

Timeline

Start: 2015-02-01
Primary completion: 2023-12-31
Completion: 2023-12-31

Publications

Alanne L, Kokki H, Mykkanen A, Orden MR, Rinne V, Rasanen J, Kokki M. Oxycodone does not affect placental circulatory physiology during the early first stage of labor-A randomized trial. Acta Obstet Gynecol Scand. 2023 Aug;102(8):1063-1072. doi: 10.1111/aogs.14603. Epub 2023 Jun 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Oxycodone	Other / unclassified	0.05 mg/kg	Intravenous

Indications

No indication recorded.