The Effect of Ticagrelor or Clopidogrel on Endothelial Function During Acute and Chronic Treatment

Summary

To investigate if treatment with ticagrelor can mitigate the transient loss of endothelium-dependent vasodilatation of the resistance vasculature following a short period of ischemia, compared with clopidogrel at standard clinical doses. The effect of ticagrelor or clopidogrel will be studied after a loading dose and after a two weeks period of regular intake on FBF in response to the vasodilators acetylcholine or nitroglycerin before and 10 min after a 20 min forearm ischemia, respectively.

Timeline

Start

2015-10

Primary completion

2016-03

Completion

2016-07

Drugs

Indications