drugset / Trial / NCT02581683

Magnesium Sulfate in Adductor Canal Blocks

NCT02581683

Phase 4 Completed 130 enrolled Queen's University
RandomizedParallel-groupQuadruple-blindTreatment

Summary

Proper analgesia after total knee arthroplasty (TKA) is important for encouraging early ambulation, which can facilitate improved patient outcomes and early hospital discharge. For pain control after TKA, adductor canal blocks (ACBs) improve upon the gold standard femoral nerve blocks (FNBs) since they do not cause as much quadriceps muscle weakening, while providing equivalent analgesia. Multimodal analgesia has become commonplace as a method of superior pain control with fewer side effects. Magnesium sulfate as an adjuvant to FNB local anesthetics can improve pain control after surgery; however, it also prolongs time to ambulation. There are no reports on the effect of magnesium sulfate in ACBs on analgesia after TKA. Thus the purpose of this randomized, double-blind, controlled trial is to determine whether magnesium sulfate given with local anesthetics via ACB can prolong analgesia, reduce pain scores and opioid consumption, and increase mobilization in TKA patients.

Timeline

Start
2015-09
Primary completion
2017-02
Completion
2017-02

Publications

Drugs

EvaluationDrugModalityDoseRoute
Subject Magnesium Sulfate Other / unclassified Other
Subject Ropivacaine Other / unclassified Other

Indications