Pharmacokinetics Study in Patients With Impaired Hepatic Function

Phase 1 Completed 24 enrolled Astellas Pharma Inc

Non-randomizedParallel-groupOpen-labelTreatment

Summary

The objective of this study is to compare and evaluate the pharmacokinetics of ASP015K in patients with impaired hepatic function and subjects with normal hepatic function.

Timeline

Start: 2015-12-28
Primary completion: 2016-09-27
Completion: 2016-09-27

Publications

Toyoshima J, Shibata M, Kaibara A, Kaneko Y, Izutsu H, Nishimura T. Population pharmacokinetic analysis of peficitinib in patients with rheumatoid arthritis. Br J Clin Pharmacol. 2021 Apr;87(4):2014-2022. doi: 10.1111/bcp.14605. Epub 2020 Dec 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	peficitinib	Small molecule	—	Oral

Indications

No indication recorded.