Effect of Rosuvastatin Therapy on HDL2 Level

Summary

In many large trials, reducing low density lipoprotein (LDL) levels with rosuvastatin decreased the incidence of major cardiovascular events，but little attention to the effects of rosuvastatin on HDL level，especially on HDL subtype. Epidemiological evidence strongly favors the notion that the risk of cardiovascular disease (CVD) is inversely related to the plasma high-density lipoprotein (HDL) cholesterol concentration. HDL can be subdivided into large-sized (HDL2a, HDL2b) and small-sized subclasses (preb1-HDL, HDL3c, HDL3b, HDL3a) and preb2-HDL. Some studies indicate that only large HDL2a and HDL2b particles make HDLs possess anti-atherogenic functions. The investigators assume that rosuvastatin could play the role of anti-atherosclerosis though the levels of HDL2a、HDL2b increased.

Timeline

Start

2015-11

Primary completion

2016-12

Completion

2017-06

Publications

• Results Tian L, Long S, Li C, Liu Y, Chen Y, Zeng Z, Fu M. High-density lipoprotein subclass and particle size in coronary heart disease patients with or without diabetes. Lipids Health Dis. 2012 May 15;11:54. doi: 10.1186/1476-511X-11-54.
• Results Pirillo A, Norata GD, Catapano AL. High-density lipoprotein subfractions--what the clinicians need to know. Cardiology. 2013;124(2):116-25. doi: 10.1159/000346463. Epub 2013 Feb 20.
• Results Navab M, Reddy ST, Van Lenten BJ, Anantharamaiah GM, Fogelman AM. The role of dysfunctional HDL in atherosclerosis. J Lipid Res. 2009 Apr;50 Suppl(Suppl):S145-9. doi: 10.1194/jlr.R800036-JLR200. Epub 2008 Oct 27.
• Results Barter P, Gotto AM, LaRosa JC, Maroni J, Szarek M, Grundy SM, Kastelein JJ, Bittner V, Fruchart JC; Treating to New Targets Investigators. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N Engl J Med. 2007 Sep 27;357(13):1301-10. doi: 10.1056/NEJMoa064278.
• Results Katabami T, Murakami M, Kobayashi S, Matsui T, Ujihara M, Takagi S, Higa M, Ichijo T, Ohta A, Tanaka Y. Efficacy of low-dose rosuvastatin in patients with type 2 diabetes and hypo high-density lipoprotein cholesterolaemia. J Int Med Res. 2014 Apr;42(2):457-67. doi: 10.1177/0300060513507648. Epub 2014 Mar 4.
• Results Kaneko K, Saito H, Takahashi T, Kiribayashi N, Omi K, Sasaki T, Niizeki T, Sugawara S, Akasaka M, Kubota I. Rosuvastatin improves plaque morphology in cerebral embolism patients with normal low-density lipoprotein and severe aortic arch plaque. J Stroke Cerebrovasc Dis. 2014 Jul;23(6):1682-9. doi: 10.1016/j.jstrokecerebrovasdis.2014.01.018. Epub 2014 Apr 13.
• Results Expert Dyslipidemia Panel of the International Atherosclerosis Society Panel members. An International Atherosclerosis Society Position Paper: global recommendations for the management of dyslipidemia--full report. J Clin Lipidol. 2014 Jan-Feb;8(1):29-60. doi: 10.1016/j.jacl.2013.12.005. Epub 2013 Dec 17.
• Results Tian L, Li C, Liu Y, Chen Y, Fu M. The value and distribution of high-density lipoprotein subclass in patients with acute coronary syndrome. PLoS One. 2014 Jan 23;9(1):e85114. doi: 10.1371/journal.pone.0085114. eCollection 2014.

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