drugset / Trial / NCT02613494
Clozapine-induced Hypersalivation - Feasibility Trial
Phase 1/2
Completed
29 enrolled
Mersey Care NHS Trust
Lancashire Care NHS Foundation Trust · collabManchester Mental Health & Social Care Trust · collabUniversity of Central Lancashire · collabUniversity of Manchester · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
A randomised placebo-controlled feasibility study of glycopyrrolate and hyoscine in the treatment of clozapine-induced hypersalivation to assess recruitment and retention rates in a multi-centre trial.
Timeline
- Start
- 2016-01-25
- Primary completion
- 2017-12-31
- Completion
- 2018-02-23
Publications
- Qurashi I, Chu S, Drake R, Hartley V, Chaudhry I, Deakin JFW, Husain N. Glycopyrrolate in comparison to hyoscine hydrobromide and placebo in the treatment of hypersalivation induced by clozapine (GOTHIC1): a feasibility study. Pilot Feasibility Stud. 2019 Jun 17;5:79. doi: 10.1186/s40814-019-0462-1. eCollection 2019.
- Qurashi I, Chu S, Husain N, Drake RJ, Chaudhry I, Deakin JF. Glycopyrrolate in comparison to hyoscine hydrobromide and placebo in the treatment of hypersalivation induced by clozapine (GOTHIC1): study protocol for a randomised controlled feasibility study. Trials. 2016 Nov 21;17(1):553. doi: 10.1186/s13063-016-1678-5.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Glycopyrrolate | Small molecule | 1 mg | — |
| Comparator | Scopolamine | Unknown | 300 ug | — |
Indications
No indication recorded.