Nebulized Analgesia for Laparoscopic Appendectomy Trial

Phase 1/2 Unknown 200 enrolled McGill University Health Centre/Research Institute of the McGill University Health Centre Montreal Children's Hospital of the MUHC · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The objective of this study is to assess whether the administration of nebulized intra-peritoneal ropivacaine at the onset of surgery, compared with nebulized saline, reduces morphine consumption after laparoscopic appendectomy surgery in children and adolescents.

Timeline

Start: 2016-01
Primary completion: 2017-06
Completion: 2017-07

Outcome

Missed primary endpoint

paper No difference was noted in overall in-patient morphine consumption between randomized groups (0.31 vs. 0.35 mg/kg, p = 0.42) PMID 30366723 ↗

Publications

Baird R, Ingelmo P, Wei A, Meghani Y, Perez EV, Pelletier H, Auer G, Mujallid R, Emil S, Laberge JM, Puligandla P, Shaw K, Poenaru D. Nebulized analgesia during laparoscopic appendectomy (NALA): A randomized triple-blind placebo controlled trial. J Pediatr Surg. 2019 Jan;54(1):33-38. doi: 10.1016/j.jpedsurg.2018.10.029. Epub 2018 Oct 5.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ropivacaine	Other / unclassified	0.5 mg/kg	Other