drugset / Trial / NCT02634606

Effects of a Supplement Derived From Palm Oil on Cholesterol Levels in the Blood

NCT02634606 ↗

Phase 3 Terminated 13 enrolled University of California, Los Angeles
RandomizedSingle-groupDouble-blindPrevention

Summary

Elevated blood cholesterol, and particularly LDL cholesterol, is a risk factor for heart disease. Tocotrienols are naturally-occurring compounds in foods that may have beneficial effects on blood cholesterol. Tocotrienols are members of the vitamin E family, and are found in barley, oats, rye, coconut oil and rice bran oil, but the richest source of tocotrienols is palm oil. Certain of these tocotrienols have been shown to be effective in lowering LDL (or 'bad') cholesterol, with no adverse effects on the HDL (or 'good') cholesterol. The purpose of this study is to determine the effects of a palm-oil derived tocotrienol supplement on blood cholesterol, and particularly LDL cholesterol, in individuals who are taking statins, and have either elevated or normal cholesterol levels. Study subjects will consume a palm-oil derived supplement of tocotrienol for 3 months to determine its effects on LDL cholesterol.

Timeline

Start
2011-03-22
Primary completion
2015-11-13
Completion
2015-11-13

Outcome

Outcome not reported

Stopped (Enrollment): “Unable to obtain supplement for this study. Unable to recruit.”

Drugs

EvaluationDrugModalityDoseRoute
Comparator Gamma Delta Tocotrienols Small molecule 63 mg Oral
Comparator Gamma Delta Tocotrienols Small molecule 127 mg Oral

Indications