HP Xenon-129 fMRI of Healthy Volunteers and Participants With Alzheimer's Disease

Summary

This study involves imaging participants' brains using MRI. The goal is to develop a high-resolution, high-sensitivity imaging tool, hyperpolarized xenon functional brain magnetic resonance imaging, which can provide more sensitive measurement of brain function, facilitating the development of drugs for more successful treatment of Alzheimer's disease.

Timeline

Start

2016-06-27

Primary completion

2022-04-19

Completion

2022-04-19

Publications

• Background Agosta F, Pievani M, Geroldi C, Copetti M, Frisoni GB, Filippi M. Resting state fMRI in Alzheimer's disease: beyond the default mode network. Neurobiol Aging. 2012 Aug;33(8):1564-78. doi: 10.1016/j.neurobiolaging.2011.06.007. Epub 2011 Aug 3.
• Background Albert MS, Cates GD, Driehuys B, Happer W, Saam B, Springer CS Jr, Wishnia A. Biological magnetic resonance imaging using laser-polarized 129Xe. Nature. 1994 Jul 21;370(6486):199-201. doi: 10.1038/370199a0.
• Results Hane FT, Li T, Plata JA, Hassan A, Granberg K, Albert MS. Inhaled Xenon Washout as a Biomarker of Alzheimer's Disease. Diagnostics (Basel). 2018 Jun 6;8(2):41. doi: 10.3390/diagnostics8020041.
• Results Grynko V, Shepelytskyi Y, Li T, Hassan A, Granberg K, Albert MS. Hyperpolarized 129 Xe multi-slice imaging of the human brain using a 3D gradient echo pulse sequence. Magn Reson Med. 2021 Dec;86(6):3175-3181. doi: 10.1002/mrm.28932. Epub 2021 Jul 17.
• Results Shepelytskyi Y, Grynko V, Rao MR, Li T, Agostino M, Wild JM, Albert MS. Hyperpolarized 129 Xe imaging of the brain: Achievements and future challenges. Magn Reson Med. 2022 Jul;88(1):83-105. doi: 10.1002/mrm.29200. Epub 2022 Mar 7.
• Results Shepelytskyi Y, Grynko V, Li T, Hassan A, Granberg K, Albert MS. The effects of an initial depolarization pulse on dissolved phase hyperpolarized 129 Xe brain MRI. Magn Reson Med. 2021 Dec;86(6):3147-3155. doi: 10.1002/mrm.28918. Epub 2021 Jul 13.
• Results Shepelytskyi Y, Hane FT, Grynko V, Li T, Hassan A, Albert MS. Hyperpolarized 129Xe Time-of-Flight MR Imaging of Perfusion and Brain Function. Diagnostics (Basel). 2020 Aug 25;10(9):630. doi: 10.3390/diagnostics10090630.

Drugs

Indications