drugset

drugset / Trial / NCT02646397

Benidipine and Hydrochlorothiazide in Fosinopril Treated Chronic Kidney Disease Patients With Hypertension

NCT02646397 ↗

Phase 4 Unknown 508 enrolled Shanghai Changzheng Hospital First Affiliated Hospital of Zhejiang University · collab Ruijin Hospital · collab Sichuan Provincial People's Hospital · collab The First Affiliated Hospital of Anhui Medical University · collab The First Affiliated Hospital of Zhengzhou University · collab The Second Affiliated Hospital of Dalian Medical University · collab Zhongda Hospital · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to compare the effect of fosinopril plus benidipine vs. fosinopril plus hydrochlorothiazide on the renal function during the 6-month treatment in CKD patients with HTN.

Timeline

Start: 2016-02
Primary completion: 2017-12
Completion: 2017-12

Publications

Xue C, Zhou C, Yang B, Lv J, Dai B, Yu S, Wang Y, Zhao G, Mei C. Comparison of efficacy and safety between benidipine and hydrochlorothiazide in fosinopril-treated hypertensive patients with chronic kidney disease: protocol for a randomised controlled trial. BMJ Open. 2017 Feb 24;7(2):e013672. doi: 10.1136/bmjopen-2016-013672.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrochlorothiazide	Unknown	12.5 mg	Oral
Subject	Hydrochlorothiazide	Unknown	25 mg	Oral
Subject	benidipine	Small molecule	4 mg	Oral
Subject	benidipine	Small molecule	8 mg	Oral
Background	Fosinopril	Small molecule	20 mg	Oral

Indications