drugset / Trial / NCT02653833

The Study of Skeletal Muscle Blood Flow in Becker Muscular Dystrophy

NCT02653833

Phase 0 Terminated 6 enrolled Cedars-Sinai Medical Center
Non-randomizedParallel-groupOpen-labelBasic science

Summary

This pilot study tests the hypothesis that the medication nitric oxide extract from beetroot juice improves blood flow to the skeletal muscle during exercise. The investigators will use cutting edge technology with contrast enhanced ultrasound to visualize the microvascular blood supply to the forearm. Animal studies have shown reversal of muscle damage with improved delivery of blood to the exercising muscle. This research aims to understand the mechanism of action of this medication in a way it has never been studied before. The results may help benefit individuals with muscular Dystrophy in the future.

Timeline

Start
2017-11-01
Primary completion
2018-09-01
Completion
2018-09-01

Drugs

EvaluationDrugModalityDoseRoute
Subject beetroot juice extract Unknown
Background Tadalafil Small molecule 20 mg

Indications