NCT02656420: Broccoli Sprout Dose Response: Bioavailability and Effects of Air Pollutants

Summary

This study will examine the extent to which lower doses of a broccoli-derived beverage enhance the detoxication of air pollutants excreted in urine as compared to an maximal dose shown to be effective previously.

Timeline

Start: 2016-01
Primary completion: 2016-03
Completion: 2016-03

Outcome

Met primary endpoint

registry analysis (equivalence test); High Dose Broccoli Sprout vs Medium Dose Broccoli Sprout vs Low Dose Broccoli Sprout; p <0.001 NCT02656420 ↗

Publications

Background Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Munoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prev Res (Phila). 2014 Aug;7(8):813-823. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.
Chen JG, Johnson J, Egner P, Ng D, Zhu J, Wang JB, Xue XF, Sun Y, Zhang YH, Lu LL, Chen YS, Wu Y, Zhu YR, Carmella S, Hecht S, Jacobson L, Munoz A, Kensler K, Rule A, Fahey J, Kensler T, Groopman J. Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China. Am J Clin Nutr. 2019 Sep 1;110(3):675-684. doi: 10.1093/ajcn/nqz122.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	broccoli sprout beverage	Unknown	0.12 mmol	Oral
Subject	broccoli sprout beverage	Unknown	0.3 mmol	Oral
Subject	broccoli sprout beverage	Unknown	0.6 mmol	Oral

Indications

No indication recorded.