Orphenadrine and Methocarbamol for LBP

Phase 4 Completed 240 enrolled Montefiore Medical Center

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Low back pain is a common cause of visit to emergency department. It is not clear if skeletal muscle relaxants are of benefit for patients with acute low back pain. This is a randomized study to determine if skeletal muscle relaxants, when combined with naproxen, improve outcomes more than naproxen alone

Timeline

Start: 2016-03
Primary completion: 2017-04
Completion: 2017-05

Publications

Friedman BW, Cisewski D, Irizarry E, Davitt M, Solorzano C, Nassery A, Pearlman S, White D, Gallagher EJ. A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain. Ann Emerg Med. 2018 Mar;71(3):348-356.e5. doi: 10.1016/j.annemergmed.2017.09.031. Epub 2017 Oct 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Methocarbamol	Small molecule	750 mg	Oral
Comparator	Orphenadrine	Small molecule	100 mg	Oral
Comparator	Naproxen	Small molecule	500 mg	Oral

Indications

No indication recorded.