Efficacy of AFL-assisted PDT in Microinvasive Squamous Cell Carcinoma

Phase 1 Completed 45 enrolled Dong-A University

RandomizedFactorialDouble-blindTreatment

Summary

Surgical excision is the standard treatment for cutaneous SCC. However, many patients diagnosed with SCC are elderly and ineligible for surgery. Ablative fractional laser- assisted photodynamic therapy (AFL-PDT) offered a higher efficacy than conventional Methylaminolevulinate (MAL)-PDT.

Timeline

Start: 2012-01
Primary completion: 2015-12
Completion: 2015-12

Publications

Choi SH, Kim KH, Song KH. Effect of Methyl Aminolevulinate Photodynamic Therapy With and Without Ablative Fractional Laser Treatment in Patients With Microinvasive Squamous Cell Carcinoma: A Randomized Clinical Trial. JAMA Dermatol. 2017 Mar 1;153(3):289-295. doi: 10.1001/jamadermatol.2016.4463.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	methyl aminolevulinate	Small molecule	16 %	Topical
Background	Lidocaine-Prilocaine	Unknown	5 %	Topical

Efficacy of AFL-assisted PDT in Microinvasive Squamous Cell Carcinoma

Summary

Timeline

Publications

Drugs

Indications