Endocrine and Emotional Effects of Lisdexamfetamine and d-Amphetamine.

Phase 1 Completed 24 enrolled University Hospital, Basel, Switzerland

RandomizedCrossoverQuadruple-blindBasic science

Summary

The study will compare the acute emotional and endocrine effects of equivalent doses of lisdexamfetamine and amphetamine in healthy subjects. In addition the pharmacokinetics and effects of the amphetamines on aspects of social cognition are investigated.

Timeline

Start: 2016-05
Primary completion: 2016-06
Completion: 2016-12

Publications

Dolder PC, Strajhar P, Vizeli P, Odermatt A, Liechti ME. Acute effects of lisdexamfetamine and D-amphetamine on social cognition and cognitive performance in a placebo-controlled study in healthy subjects. Psychopharmacology (Berl). 2018 May;235(5):1389-1402. doi: 10.1007/s00213-018-4849-0. Epub 2018 Feb 9.
Dolder PC, Strajhar P, Vizeli P, Hammann F, Odermatt A, Liechti ME. Pharmacokinetics and Pharmacodynamics of Lisdexamfetamine Compared with D-Amphetamine in Healthy Subjects. Front Pharmacol. 2017 Sep 7;8:617. doi: 10.3389/fphar.2017.00617. eCollection 2017.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dextroamphetamine	Small molecule	40.3 mg	Oral
Subject	Lisdexamfetamine	Other / unclassified	100 mg	Oral

Indications

No indication recorded.