The Application of Docozine Combined With Sufentanil for Awake Tracheal Intubation
Summary
Mortality associated with difficult airway in anesthesia is up to 30%. So, it is urgent to find a safe and effective method for intubation. Awake tracheal intubation which is used to retain spontaneous breathing is one of the important measures to ensure the safety of the patients with difficult airway in anesthesia. Sufentanil is used to provide good analgesia and can effectively inhibit the reaction of awake tracheal intubation, however, the outstanding problem is serious respiratory depression after intravenous sufentanil injection. Few study showed that dezocine is a kappa opioid antagonist related to mild respiratory depression and can prevents sufentanil-induced cough during general anesthesia induction.It is necessary to carry out large-scale, multi-center, randomized, controlled clinical study to determine whether dezocine prevents sufentanil-induced respiratory depression and whether dezocine combined sufentanil is a safe and effective method for awake tracheal intubation.
Timeline
- Start
- 2016-03
- Primary completion
- 2018-08
- Completion
- 2018-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dezocine | Other / unclassified | 0.05 mg/kg | — |
| Subject | Dezocine | Other / unclassified | 0.1 mg/kg | — |
| Subject | Dezocine | Other / unclassified | 0.15 mg/kg | — |
Indications
No indication recorded.