DHEA in Synovial Sarcoma Patients

Summary

DHEA is a natural allosteric inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PD is a key regulatory enzyme for the survival of synovial sarcoma. The investigators postulate that they can inhibit the production of NADPH in synovial sarcoma and cause cell death by using a naturally occurring G6PD inhibitor.

Timeline

Start

2016-09-13

Primary completion

2018-09-09

Completion

2019-04-04

Outcome

Outcome not reported

Stopped: “The trial did not show any positive effects.”

Drugs

Indications