Night Time Use of Thiazide Diuretics for Improved Reduction in Stone Risk in Stone Formers With Elevated Urine Calcium

Summary

Thiazide diuretics will be more effective in lowering urine calcium excretion if taken at night as compared to the daytime. It will therefore be more effective in reducing kidney stone recurrence in nephrolithiasis patients with elevated urine calcium who are known to have increased risk of kidney stones at night time.

Timeline

Start

2014-02

Primary completion

2017-06

Completion

2017-06

Publications

• Wollin DA, Fattah H, Asplin JR, Goldfarb DS. Effect of Chlorthalidone and Hydrochlorothiazide on 12-Hour vs 24-Hour Urinary Calcium Excretion. J Urol. 2025 Sep;214(3):280-288. doi: 10.1097/JU.0000000000004562. Epub 2025 Apr 7.

Drugs

Indications