Effects of Seminal Plasma on Pregnancy Rate With IVF

Summary

All couples planned for IVF will be asked to participate. After information and received informed consent they will be randomized into two groups. At the time for ovum pick up during an IVF procedure either half of the amount of seminal plasma or the same amount of physiological NaCl solution will be installed around the external cervical opening in vagina. The syringe with seminal plasma or physiological NaCl solution will be prepared according to a prearranged randomization list by a technician. The success rate will be the number of diagnosed pregnancies and live births.

Timeline

Start

2016-11

Primary completion

2023-03

Completion

2023-03

Outcome

Missed primary endpoint

paper Prepared seminal plasma applied in the vagina directly after OPU did not increase the rates of LB or clinical pregnancies. PMID 38342372 ↗

Publications

• Liffner S, Bladh M, Rodriguez-Martinez H, Sydsjo G, Zalavary S, Nedstrand E. Intravaginal exposure to seminal plasma after ovum pick-up does not increase live birth rates after in vitro fertilization or intracytoplasmic sperm injection treatment: a double-blind, placebo-controlled randomized trial. Fertil Steril. 2024 Jul;122(1):131-139. doi: 10.1016/j.fertnstert.2024.02.002. Epub 2024 Feb 9.

Drugs

Indications