Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter

Phase 2 Unknown 74 enrolled Medical University of Vienna

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The study at hand is the first to investigate ketamine's SERT binding in humans, by utilizing the highly selective SERT radioligand \[11C\]DASB and positron emission tomography.

Timeline

Start: 2016-05
Primary completion: 2019-12-31
Completion: 2019-12-31

Publications

Spies M, James GM, Berroteran-Infante N, Ibeschitz H, Kranz GS, Unterholzner J, Godbersen M, Gryglewski G, Hienert M, Jungwirth J, Pichler V, Reiter B, Silberbauer L, Winkler D, Mitterhauser M, Stimpfl T, Hacker M, Kasper S, Lanzenberger R. Assessment of Ketamine Binding of the Serotonin Transporter in Humans with Positron Emission Tomography. Int J Neuropsychopharmacol. 2018 Feb 1;21(2):145-153. doi: 10.1093/ijnp/pyx085.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Esketamine	Other / unclassified	0.25 mg/kg	Intravenous
Subject	Esketamine	Other / unclassified	0.3 mg/kg	Intravenous
Subject	Esketamine	Other / unclassified	0.5 mg/kg	Intravenous
Subject	Esketamine	Other / unclassified	0.6 mg/kg	Intravenous
Subject	Esketamine	Other / unclassified	0.8 mg/kg	Intravenous

Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter

Summary

Timeline

Publications

Drugs

Indications