drugset / Trial / NCT02721186
Effectiveness of Mass Drug Administration for Reducing Seasonal Malaria Transmission in Zanzibar
Completed
22500 enrolled
Ulrika Morris
Mahidol Oxford Tropical Medicine Research Unit · collabRTI International · collabThe President's Malaria Initiative · collabUniversity of California, San Francisco · collabUppsala University · collabZanzibar Malaria Elimination Programme · collab
RandomizedParallel-groupOpen-labelPrevention
Summary
The overall aim of this study is to determine the effectiveness of two rounds of mass drug administration (MDA) with dihydroartemisinin-piperaquine (DHAp) + single low dose (SLD) primaquine for reducing seasonal malaria transmission in Shehias considered hotspots on Unguja Island, Zanzibar.
Timeline
- Start
- 2016-04-30
- Primary completion
- 2016-12-31
- Completion
- 2017-09-30
Outcome
Missed primary endpoint
paper No difference in cumulative malaria case incidence was observed between the control and intervention arms 6 months post-MDA (4.2 and 3.9 per 1000 population; p = 0.94). PMID 30526588 ↗
paper Neither was there a difference in PCR-determined parasite prevalences 3 months post-MDA (1.4% and 1.7%; OR = 1.0, p = 0.94) PMID 30526588 ↗
Publications
- Shah MP, Hwang J, Choi L, Lindblade KA, Kachur SP, Desai M. Mass drug administration for malaria. Cochrane Database Syst Rev. 2021 Sep 29;9(9):CD008846. doi: 10.1002/14651858.CD008846.pub3.
- Morris U, Msellem MI, Mkali H, Islam A, Aydin-Schmidt B, Jovel I, Shija SJ, Khamis M, Ali SM, Hodzic L, Magnusson E, Poirot E, Bennett A, Sachs MC, Tarning J, Martensson A, Ali AS, Bjorkman A. A cluster randomised controlled trial of two rounds of mass drug administration in Zanzibar, a malaria pre-elimination setting-high coverage and safety, but no significant impact on transmission. BMC Med. 2018 Dec 10;16(1):215. doi: 10.1186/s12916-018-1202-8.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dihydroartemisinin-piperaquine | Unknown | — | — |
| Subject | Primaquine | Small molecule | 0.25 mg/kg | — |