Role of Intravenous Versus Home Oral Antibiotics in Perforated Appendicitis
Summary
To compare the effect of a single-agent home intravenous (IV) versus oral antibiotic therapy on complication rates and resource utilization following appendectomy for perforated appendicitis
Timeline
- Start
- 2011-01
- Primary completion
- 2013-11
- Completion
- 2013-11
Outcome
Mixed primary results
registry COUNT_OF_PARTICIPANTS Home Intravenous Ertapenem and PICC: 5 Participants NCT02724410 ↗
registry COUNT_OF_PARTICIPANTS Home Oral Amoxicillin-clavulanate: 3 Participants NCT02724410 ↗
registry analysis (other test); Home Intravenous Ertapenem and PICC vs Home Oral Amoxicillin-clavulanate; p = 0.7188; Chi-squared NCT02724410 ↗
registry MEAN Home Intravenous Ertapenem and PICC: 47564.3 (Standard Deviation 9057.59) Dollars NCT02724410 ↗
registry MEAN Home Oral Amoxicillin-clavulanate: 34227.79 (Standard Deviation 8104.65) Dollars NCT02724410 ↗
registry analysis (other test); Home Intravenous Ertapenem and PICC vs Home Oral Amoxicillin-clavulanate; p <.0001; Wilcoxon (Mann-Whitney) NCT02724410 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Amoxicillin-clavulanate | Other / unclassified | 15 mg/kg | Oral |
| Subject | Amoxicillin-clavulanate | Other / unclassified | 22.5 mg/kg | Oral |
| Comparator | Ertapenem | Small molecule | 15 mg/kg | Intravenous |
| Comparator | Ertapenem | Small molecule | 1 g | Intravenous |