Cardio-respiratory Events and Inflammatory Response After Primary Immunization in Preterm Infants

Summary

Background: Inflammation may depress respiration in neonates. The aim of this study was to establish a link between post-immunization inflammation and cardio-respiratory events (CRE). Methods: Randomized double-blind controlled study of infants born \<32 weeks gestation receiving the 2 months vaccine. Infants were randomized into an ibuprofen treatment group and a placebo control group. C-reactive protein (CRP) and prostaglandins E2 (PgE2) levels were assessed before and after immunization. CRE were recorded for 72 hours. Heart rate variability (HRV) was assessed by polysomnography.

Timeline

Start

2010-02

Primary completion

2011-03

Completion

2012-04

Publications

• Background Hoch B, Bernhard M. Central apnoea and endogenous prostaglandins in neonates. Acta Paediatr. 2000 Nov;89(11):1364-8. doi: 10.1080/080352500300002589.
• Background Schulzke S, Heininger U, Lucking-Famira M, Fahnenstich H. Apnoea and bradycardia in preterm infants following immunisation with pentavalent or hexavalent vaccines. Eur J Pediatr. 2005 Jul;164(7):432-5. doi: 10.1007/s00431-005-1674-3. Epub 2005 Apr 21.

Drugs

Indications