drugset / Trial / NCT02727101
Perampanel for Treatment of Adults With Refractory Focal Epilepsy : a Pilot Study.
Non-randomizedSingle-groupOpen-labelTreatment
Summary
The goal of the present study is to evaluate ("screen") a large number (12) of different dual therapies of perampanel + another AED ("PMP+") for a large, 75-100% seizure frequency reduction. The design of the study will differ from usual AED studies. The study will be (i) open label, with (ii) a small n per group, n=6, with (iii) outcome measures a 'blockbuster effect': (a) ≥75 seizure frequency reduction; and (b) seizure freedom.
Timeline
- Start
- 2015-11
- Primary completion
- 2017-07
- Completion
- 2017-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Perampanel | Small molecule | 8 mg | — |
| Comparator | Perampanel | Small molecule | 12 mg | — |