drugset / Trial / NCT02732184

A Multiple Dose, Dose Escalation Trial of AEB1102 in Patients With AML or MDS

NCT02732184

Phase 2 Completed 29 enrolled Aeglea Biotherapeutics
NaSingle-groupOpen-labelTreatment

Summary

This is the first study of the safety of increasing dose levels of AEB1102 in patients with Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome. The study will also evaluate the amounts of AEB1102 in blood, the effects of AEB1102 on blood amino acid levels and the antitumor effects of AEB1102.

Timeline

Start
2016-08
Primary completion
2017-12
Completion
2017-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Pegzilarginase Protein / enzyme biologic Intravenous